Maximilian Billmann
University of Bonn, University Hospital Bonn
Biography
We explore how genes interact in networks to regulate cells. We are particularly interested to learn how such functional interactions respond to environmental changes and how this functional capacity is impacted by disease-associated genetic variants. To this end, we develop computational methods to infer mechanistic cues from of large-scale perturbation data such as the Cancer Dependency Map (DepMap), single-cell-based CRISPR experiments, the currently ongoing human Genetic Interaction Network (GIN) or tissue type-resolved expression atlases. Our methods aim at understanding and utilizing different types of perturbation data, improving data reproducibility and guide experimental efforts to maximize the information gain towards a DepMap that covers genetic, environmental and phenotypic complexity of a cancer cell.
Relevant Publications
- N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevityVarland S., Silva R.D., Kjosas I., et al., Nature Communications (2023).
- Dimensionality reduction methods for extracting functional networks from large-scale CRISPR screensHassan A.Z., Ward H.N., Rahman M., Billmann M., Lee Y., Myers C.L., Molecular Systems Biology (2023).
- Reproducibility metrics for context-specific CRISPR screensBillmann M.+, Ward H.N., Aregger M., et al., Cell Systems (2023).
- A method for benchmarking genetic screens reveals a predominant mitochondrial biasRahman M.*, Billmann M.*,+, Costanzo M., et al., Molecular Systems Biology (2021).
- Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolismAregger M.*, Lawson K.*, Billmann M.*, Costanzo M., et al., Nature Metabolism (2020).
- Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9-Cas12a platformGonatopoulos-Pourzatzis T., Aregger M., Brown K.R., et al., Nature Biotechnology (2020).
- Widespread rewiring of genetic networks upon cancer signaling pathway activationBillmann M., Chaudhary V., ElMaghraby M., Fischer B., Boutros M., Cell Systems (2018).
- A global genetic interaction network maps a wiring diagram of cellular functionCostanzo M., VanderSluis B., Koch E.N., Baryshnikova A., et al., Science (2016).
- A genetic interaction map of cell cycle regulatorsBillmann M.*, Horn T.*, Fischer B., Sandmann T., Huber W., Boutros M., Molecular Biology of the Cell (2016).
- A map of directional genetic interactions in a metazoan cellFischer B.*, Sandmann T.*, Horn T.*, Billmann M.*, Chaudhary V., Huber W., Boutros M., eLife (2015).