Michael Boutros

Relevant Publications

• Improved in vivo gene knockout with high specificity using multiplexed Cas12a sgRNAs
  Port F., Buhmann M.A., Zhou J., Stricker M., Vaughan-Brown A., Michalsen A.-C., Roßmanith E., Pöltl A., Großkurth L., Huber J., Menendez Kury L.B., Weberbauer B., Hübl M., Puscher E., Heigwer F., Boutros M., Nature Communications (2026).
  10.1038/s41467-026-68434-z
• UNCAN.eu: Toward a European Federated Cancer Research Data Hub
  Boutros M., Baumann M., Bigas A., Chaabane L., Guérin J., Habermann J.K., Jobard A., Pelicci P.G., Stegle O., Tonon G., Valencia A., Winkler E.C., Blanc P., De Maria R., Medema R.H., Nagy P., Tabernero J., Solary E., Cancer Discovery (2024).
  10.1158/2159-8290.CD-23-1111
• A global genetic interaction network by single cell imaging and machine learning
  Heigwer F., Scheeder C., Bageritz J., Yousefian S., Rauscher B., Laufer C., Beneyto Calabuig S., Funk M.C., Peters V., Boulougouri M., Bilanovic J., Miersch T., Schmitt B., Blass C., Port F., Boutros M., Cell Systems (2023).
  10.1016/j.cels.2023.03.003
• Metabolic balance in colorectal cancer is maintained by optimal Wnt signaling levels
  Imkeller K., Ambrosi G., Klemm N., Claveras Cabezudo A., Henkel L., Huber W., Boutros M., Molecular Systems Biology (2022).
  10.15252/msb.202110874
• The drug-induced phenotypic landscape of colorectal cancer organoids
  Betge J., Rindtorff N., Sauer J., Rauscher B., Dingert C., Gaitantzi H., Herweck F., Srour-Mhanna K., Miersch T., Valentini E., Boonekamp K.E., Hauber V., Gutting T., Frank L., Belle S., Gaiser T., Buchholz I., Jesenofsky R., Härtel N., Zhan T., Fischer B., Breitkopf-Heinlein K., Burgermeister E., Ebert M.P., Boutros M., Nature Communications (2022).
  10.1038/s41467-022-30722-9
• gscreend: modelling asymmetric count ratios in CRISPR screens to decrease experiment size and improve phenotype detection
  Imkeller K., Ambrosi G., Boutros M., Huber W., Genome Biology (2020).
  10.1186/s13059-020-1939-1
• MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer
  Zhan T., Ambrosi G., Wandmacher A.M., Rauscher B., Betge J., Rindtorff N., Häussler R.S., Hinsenkamp I., Bamberg L., Hessling B., Müller-Decker K., Erdmann G., Burgermeister E., Ebert M.P., Boutros M., Nature Communications (2019).
  10.1038/s41467-019-09898-0
• Time-resolved mapping of genetic interactions to model rewiring of signaling pathways
  Heigwer F., Scheeder C., Miersch T., Schmitt B., Blass C., Vali Pour-Jamnani M., Boutros M., eLife (2018).
  10.7554/eLife.40174
• Widespread rewiring of genetic networks upon cancer signaling pathway activation
  Billmann M., Chaudhary V., ElMaghraby M., Fischer B., Boutros M., Cell Systems (2018).
  10.1016/j.cels.2017.10.015
• Toward an integrated map of genetic interactions in cancer cells
  Rauscher B., Heigwer F., Henkel L., Hielscher T., Voloshanenko O., Boutros M., Molecular Systems Biology (2018).
  10.15252/msb.20177656