Pedro Beltrao

ETH Zürich

Biography

Pedro Beltrao has a Biochemistry degree from University of Coimbra (2002) and a PhD in Biology from the University of Aveiro for research conducted at EMBL-Heidelberg under the supervision of Luis Serrano (2007). He did his postdoctoral research at the University of California San Francisco under the supervision of Prof. Nevan Krogan (2008-2012). He was a group leader at EMBL-EBI from 2013 to 2021 and he is now an Associate Professor at the Department of Biology, ETH Zurich since Jan 2022. His research group aims to develop an integrated understanding of the mechanisms that underlie the relation between genotype and phenotype with a specific focus on human trait variation and disease.

Relevant Publications

A tissue-specific atlas of protein-protein associations enables prioritization of candidate disease genes

Laman Trip D. S., van Oostrum M., Memon D., Frommelt F., Baptista D., Panneerselvam K., Bradley G., Licata L., Hermjakob H., Orchard S., Trynka G., McDonagh E. M., Fossati A., Aebersold R., Gstaiger M., Wollscheid B., Beltrao P., Nature Biotechnology (2025).

https://doi.org/10.1038/s41587-025-02659-z
Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival

Sousa A., Dugourd A., Memon D., Petursson B., Petsalaki E., Saez-Rodriguez J., Beltrao P., Molecular Systems Biology (2023).

https://doi.org/10.15252/msb.202110631
Network expansion of genetic associations defines a pleiotropy map of human cell biology

Barrio-Hernandez I., Schwartzentruber J., Shrivastava A., del-Toro N., Gonzalez A., Zhang Q., Mountjoy E., Suveges D., Ochoa D., Ghoussaini M., Bradley G., Hermjakob H., Orchard S., Dunham I., Anderson C. A., Porras P., Beltrao P., Nature Genetics (2023).

https://doi.org/10.1038/s41588-023-01327-9
A structural biology community assessment of AlphaFold 2 applications

Akdel M., Pires D. E. V., Porta-Pardo E., Jänes J., Zalevsky A. O., Mészáros B., Bryant P., Good L. L., Laskowski R. A., Pozzati G., Shenoy A., Zhu W., Kundrotas P., Ruiz-Serra V., Rodrigues C. H. M., Dunham A. S., Burke D., Borkakoti N., Velankar S., Frost A., Basquin J., Lindorff-Larsen K., Bateman A., Kajava A. V., Valencia A., Ovchinnikov S., Durairaj J., Ascher D. B., Thornton J. M., Davey N. E., Stein A., Elofsson A., Croll T. I., Beltrao P., Nature Structural & Molecular Biology (2022).

https://doi.org/10.1038/s41594-022-00849-w
Exploring amino acid functions in a deep mutational landscape

Dunham A. S., Beltrao P., Molecular Systems Biology (2021).

https://doi.org/10.15252/msb.202110305
Copy number aberrations drive kinase rewiring, leading to genetic vulnerabilities in cancer

Memon D., Gill M. B., Papachristou E. K., Ochoa D., D'Santos C. S., Miller M. L., Beltrao P., Cell Reports (2021).

https://doi.org/10.1016/j.celrep.2021.109155
Sequence and Structure-Based Analysis of Specificity Determinants in Eukaryotic Protein Kinases

Bradley D., Viéitez C., Rajeeve V., Selkrig J., Cutillas P. R., Beltrao P., Cell Reports (2021).

https://doi.org/10.1016/j.celrep.2020.108602
Prediction of Signed Protein Kinase Regulatory Circuits

Invergo B. M., Petursson B., Akhtar N., Bradley D., Giudice G., Hijazi M., Cutillas P., Petsalaki E., Beltrao P., Cell Systems (2020).

https://doi.org/10.1016/j.cels.2020.04.005
The functional landscape of the human phosphoproteome

Ochoa D., Jarnuczak A. F., Viéitez C., Gehre M., Soucheray M., Mateus A., Kleefeldt A. A., Hill A., Garcia-Alonso L., Stein F., Krogan N. J., Savitski M. M., Swaney D. L., Vizcaíno J. A., Noh K., Beltrao P., Nature Biotechnology (2020).

https://doi.org/10.1038/s41587-019-0344-3
Widespread Post-transcriptional Attenuation of Genomic Copy-Number Variation in Cancer

Gonçalves E., Fragoulis A., Garcia-Alonso L., Cramer T., Saez-Rodriguez J., Beltrao P., Cell Systems (2017).

https://doi.org/10.1016/j.cels.2017.08.013